Celltrion

Dear Valued Shareholders,

To address market concerns arising from recent references to changes in U.S. government tariff policies, we would like to share with our shareholders the current operational status of the Branchburg facility and our forward plans as follows.

Initiation of CMO Production and Validation for In-House Product Manufacturing

Following the successful completion of the acquisition of the former Eli Lilly facility late last year, we finalized a comprehensive inspection of the entire site and completed all preparations for full-scale operations by the end of January this year. Based on these efforts, we commenced full-scale production of Lilly CMO products across all lines beginning in February, thereby demonstrating the operational efficiency of our U.S. manufacturing facility.

In parallel, Celltrion has initiated validation procedures required for the manufacturing of its own products. By integrating local manufacturing with its direct commercial network, we plan to establish a fully integrated system capable of supplying locally manufactured products to the U.S. market in due course.

Structural Mitigation of Tariff Risks and Completion of Preemptive Measures

Celltrion has completed all necessary measures to ensure that its business operations remain unaffected, regardless of how future U.S. tariff issues may unfold.

• Short-term Response: Sales will continue without tariff impact through the utilization of approximately two years of inventory already positioned within the United States.
• Mid- to long-term Response: Direct supply of products from the Branchburg manufacturing facility will enable the operation of a production-and-sales system that is fully insulated from tariff-related issues.

In conclusion, despite the U.S. Supreme Court’s ruling invalidating reciprocal tariffs and the potential for future changes in tariff policy under the Trump administration, we have established a structurally resilient local production and supply system, ensuring that its operations remain unaffected by tariff-related uncertainties.

Celltrion remains focused on closely monitoring local market conditions and making every effort to safeguard shareholder value. We sincerely appreciate our shareholders’ continued trust and support.